منابع مشابه
Phytosome - more bioavailable
For good bioavailability, natural products must have a good balance between hydrophilicity (for dissolving into the gastro-intestinal fluids) and lipophilicity (to cross lipidic biomembranes). Many phytoconstituents like glycosilated polyphenolics have good water solubility, but are, nevertheless, poorly absorbed[1] because of their large size, incompatible with a process of passive diffusion a...
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Owing to the requirement of surgical senior house officers to prioritise acute admissions in the accident and emergency department, they are increasingly unable to be present in theatre to assist the surgical registrar. As a consequence, the surgeon has to rely on the scrub team to provide much-needed retraction with cases such as open appendicectomies. We have found the use of the Alexis® woun...
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Alexander, Aaron D. (Walter Reed Army Institute of Research, Washington, D.C.), Herbert G. Stoenner, Garnett E. Wood, and Robert J. Byrne. A new pathogenic Leptospira, not readily cultivated. J. Bacteriol. 83:754-760. 1962.-A pathogenic Leptospira was isolated from water of the Grand River, (S.D.) that differed significantly from other known leptospirae in that it could not be cultivated in con...
متن کاملOrally bioavailable potent soluble epoxide hydrolase inhibitors.
A series of N,N'-disubstituted ureas having a conformationally restricted cis- or trans-1,4-cyclohexane alpha to the urea were prepared and tested as soluble epoxide hydrolase (sEH) inhibitors. This series of compounds showed low nanomolar to picomolar activities against recombinant human sEH. Both isomers showed similar potencies, but the trans isomers were more metabolically stable in human h...
متن کاملSerum bioavailable testosterone: assayed or calculated?
BACKGROUND Bioavailable testosterone (BT), circulating testosterone not bound to sex hormone-binding globulin (SHBG), is thought to easily penetrate cells. We compared BT measurements obtained by assays with those obtained by calculation with different testosterone association constants. METHODS We obtained sera from 2 groups of hypogonadal men [group 1 (G1), 1421 samples; group 2 (G2), 170 s...
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ژورنال
عنوان ژورنال: Nature Energy
سال: 2020
ISSN: 2058-7546
DOI: 10.1038/s41560-020-0592-y